Numerical investigation of airborne contaminant transport under different vortex structures in the aircraft cabin.

Airborne contaminants such as pathogens, odors and CO2 released from an individual passenger could spread via air flow in an aircraft cabin and make other passengers unhealthy and uncomfortable. In this study, we introduced the airflow vortex structure to analyze how airflow patterns affected contaminant transport in an aircraft cabin. Experimental data regarding airflow patterns were used to validate a computational fluid dynamics (CFD) model. Using the validated CFD model, we investigated the effects of the airflow vortex structure on contaminant transmission based on quantitative analysis. It was found that the contaminant source located in a vorticity-dominated region was more likely to be "locked" in the vortex, resulting in higher 62% higher average concentration and 14% longer residual time than that when the source was on a deformation dominated location. The contaminant concentrations also differed between the front and rear parts of the cabin because of different airflow structures. Contaminant released close to the heated manikin face was likely to be transported backward according to its distribution mean position. Based on these results, the air flow patterns inside aircraft cabins can potentially be improved to better control the spread of airborne contaminant

Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century.

Air pollution is a severe threat to public health globally, affecting everyone in developed and developing countries alike. Among different air pollutants, particulate matter (PM), particularly combustion-produced fine PM (PM2.5) has been shown to play a major role in inducing various adverse health effects. Strong associations have been demonstrated by epidemiological and toxicological studies between increases in PM2.5 concentrations and premature mortality, cardiopulmonary diseases, asthma and allergic sensitization, and lung cancer. The mechanisms of PM-induced toxicological effects are related to their size, chemical composition, lung clearance and retention, cellular oxidative stress responses and pro-inflammatory effects locally and systemically. Particles in the ultrafine range (<100 nm), although they have the highest number counts, surface area and organic chemical content, are often overlooked due to insufficient monitoring and risk assessment. Yet, ample studies have demonstrated that ambient ultrafine particles have higher toxic potential compared with PM2.5. In addition, the rapid development of nanotechnology, bringing ever-increasing production of nanomaterials, has raised concerns about the potential human exposure and health impacts. All these add to the complexity of PM-induced health effects that largely remains to be determined, and mechanistic understanding on the toxicological effects of ambient ultrafine particles and nanomaterials will be the focus of studies in the near future

Algorithms for VLSI Circuit Optimization and GPU-Based Parallelization

This research addresses some critical challenges in various problems of VLSI design automation, including sophisticated solution search on DAG topology, simultaneous multi-stage design optimization, optimization on multi-scenario and multi-core designs, and GPU-based parallel computing for runtime acceleration. Discrete optimization for VLSI design automation problems is often quite complex, due to the inconsistency and interference between solutions on reconvergent paths in directed acyclic graph (DAG). This research proposes a systematic solution search guided by a global view of the solution space. The key idea of the proposal is joint relaxation and restriction (JRR), which is similar in spirit to mathematical relaxation techniques, such as Lagrangian relaxation. Here, the relaxation and restriction together provides a global view, and iteratively improves the solution. Traditionally, circuit optimization is carried out in a sequence of separate optimization stages. The problem with sequential optimization is that the best solution in one stage may be worse for another. To overcome this difficulty, we take the approach of performing multiple optimization techniques simultaneously. By searching in the combined solution space of multiple optimization techniques, a broader view of the problem leads to the overall better optimization result. This research takes this approach on two problems, namely, simultaneous technology mapping and cell placement, and simultaneous gate sizing and threshold voltage assignment. Modern processors have multiple working modes, which trade off between power consumption and performance, or to maintain certain performance level in a powerefficient way. As a result, the design of a circuit needs to accommodate different scenarios, such as different supply voltage settings. This research deals with this multi-scenario optimization problem with Lagrangian relaxation technique. Multiple scenarios are taken care of simultaneously through the balance by Lagrangian multipliers. Similarly, multiple objective and constraints are simultaneously dealt with by Lagrangian relaxation. This research proposed a new method to calculate the subgradients of the Lagrangian function, and solve the Lagrangian dual problem more effectively. Multi-core architecture also poses new problems and challenges to design automation. For example, multiple cores on the same chip may have identical design in some part, while differ from each other in the rest. In the case of buffer insertion, the identical part have to be carefully optimized for all the cores with different environmental parameters. This problem has much higher complexity compared to buffer insertion on single cores. This research proposes an algorithm that optimizes the buffering solution for multiple cores simultaneously, based on critical component analysis. Under the intensifying time-to-market pressure, circuit optimization not only needs to find high quality solutions, but also has to come up with the result fast. Recent advance in general purpose graphics processing unit (GPGPU) technology provides massive parallel computing power. This research turns the complex computation task of circuit optimization into many subtasks processed by parallel threads. The proposed task partitioning and scheduling methods take advantage of the GPU computing power, achieve significant speedup without sacrifice on the solution quality

Blood Pressure Control Goals in Elderly Patients with Hypertension：Evidence from Latest Clinical Studies

Due to the lack of relevant research evidence, the optimal blood pressure target in elderly hypertensive patients has been controversial for a long time. Many scholars believe that the elderly have poor tolerance to antihypertensive treatment, so their blood pressure control goal should bemore relaxed. However, the latest research evidence published in recent years shows that there may be more benefits from controlling systolic blood pressure in older adults to <130 mmHg. It is expected that these new research conclusions will have an important impact on the revision of guidelines in the future

HAMNER: Headword Amplified Multi-span Distantly Supervised Method for Domain Specific Named Entity Recognition

To tackle Named Entity Recognition (NER) tasks, supervised methods need to obtain sufficient cleanly annotated data, which is labor and time consuming. On the contrary, distantly supervised methods acquire automatically annotated data using dictionaries to alleviate this requirement. Unfortunately, dictionaries hinder the effectiveness of distantly supervised methods for NER due to its limited coverage, especially in specific domains. In this paper, we aim at the limitations of the dictionary usage and mention boundary detection. We generalize the distant supervision by extending the dictionary with headword based non-exact matching. We apply a function to better weight the matched entity mentions. We propose a span-level model, which classifies all the possible spans then infers the selected spans with a proposed dynamic programming algorithm. Experiments on all three benchmark datasets demonstrate that our method outperforms previous state-of-the-art distantly supervised methods.Comment: 9 pages, 2 figure

Chapter SOA-Based Aeronautical Service Integration

Space scienc

Spectroscopic study of light scattering in linear alkylbenzene for liquid scintillator neutrino detectors

We has set up a light scattering spectrometer to study the depolarization of light scattering in linear alkylbenzene. From the scattering spectra it can be unambiguously shown that the depolarized part of light scattering belongs to Rayleigh scattering. The additional depolarized Rayleigh scattering can make the effective transparency of linear alkylbenzene much better than it was expected. Therefore sufficient scintillation photons can transmit through the large liquid scintillator detector of JUNO. Our study is crucial to achieving the unprecedented energy resolution 3\%/$\sqrt{E\mathrm{(MeV)}}$ for JUNO experiment to determine the neutrino mass hierarchy. The spectroscopic method can also be used to judge the attribution of the depolarization of other organic solvents used in neutrino experiments.Comment: 6 pages, 5 figure